Protein-protein interactions (PPIs) play a significant role in the regulation of cell cycle progression, apoptosis, and DNA repair mechanisms. Aberrations in these interactions can lead to uncontrolled cell growth, resistance to cell death, and genomic instability, all of which are hallmarks of cancer. For instance, the interaction between the p53 tumor suppressor protein and its negative regulator MDM2 is a well-studied example. Dysregulation of this interaction can lead to the inactivation of p53, promoting tumor development.
