Slingshot proteins are phosphatases that deactivate cofilin by removing phosphate groups. When cofilin is active, it binds to actin filaments and facilitates their disassembly. This process is crucial for cell movement and morphological changes. By modulating cofilin activity, Slingshot proteins play a pivotal role in the reorganization of the cytoskeleton, which is a key factor in the invasiveness of cancer cells.
