What is the Role of Slingshot in Cancer Metastasis?
Metastasis involves multiple steps, including cell detachment from the primary tumor, invasion into surrounding tissues, and eventual colonization of distant organs. Slingshot proteins, by regulating cofilin activity, facilitate the remodeling of the actin cytoskeleton, which is crucial for these processes. Increased Slingshot activity has been linked to enhanced motility and invasiveness of cancer cells, making it a critical player in the metastatic cascade.
