How Do Targeted Therapies Affect Cell Cycle Control in Cancer?
Targeted therapies aim to specifically inhibit molecules involved in cancer cell proliferation. Examples include: - CDK Inhibitors: Drugs like palbociclib inhibit CDKs, thereby halting cell cycle progression in cancer cells. - PARP Inhibitors: These drugs exploit deficiencies in DNA repair pathways in cancer cells, leading to cell death. - Checkpoint Inhibitors: Drugs targeting immune checkpoints (e.g., PD-1/PD-L1) can enhance the immune system's ability to destroy cancer cells.
