How Does ABCC1 Contribute to Drug Resistance in Cancer?
One of the significant challenges in cancer treatment is the development of drug resistance. ABCC1 is heavily implicated in this process. By actively pumping out a range of chemotherapeutic drugs from cancer cells, ABCC1 reduces the intracellular concentration of these drugs, thus diminishing their efficacy. This mechanism is a primary reason for the failure of many standard chemotherapy regimens.
