abcc1

What Are the Potential Strategies to Overcome ABCC1-Mediated Drug Resistance?

Several strategies have been explored to counteract ABCC1-mediated drug resistance:
Inhibitors of ABCC1: Compounds that can block the activity of ABCC1 may help in retaining chemotherapeutic agents within the cancer cells.
Combination Therapy: Using a combination of drugs that are not substrates for ABCC1 along with those that are can potentially bypass the resistance mechanism.
Gene Silencing: Techniques like RNA interference (RNAi) are being investigated to reduce the expression of ABCC1 in cancer cells.

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