What Are the Potential Strategies to Overcome ABCC1-Mediated Drug Resistance?
Several strategies have been explored to counteract ABCC1-mediated drug resistance:
Inhibitors of ABCC1: Compounds that can block the activity of ABCC1 may help in retaining chemotherapeutic agents within the cancer cells. Combination Therapy: Using a combination of drugs that are not substrates for ABCC1 along with those that are can potentially bypass the resistance mechanism. Gene Silencing: Techniques like RNA interference (RNAi) are being investigated to reduce the expression of ABCC1 in cancer cells.