How Does DNA Methylation Contribute to Gene Silencing?
DNA methylation involves the addition of a methyl group to the DNA molecule, typically at cytosine bases in CpG islands. In cancer, abnormal DNA methylation patterns can silence tumor suppressor genes, such as p53 and BRCA1, leading to unchecked cell division and tumor growth. This epigenetic alteration is reversible, making it a potential target for therapeutic intervention.
