How does Fatty Acid Synthase (FASN) contribute to cancer progression?
Fatty Acid Synthase (FASN) is overexpressed in many cancers, including breast, prostate, and ovarian cancers. FASN catalyzes the synthesis of palmitate, a saturated fatty acid, which is a precursor for complex lipids required by rapidly dividing cancer cells. Inhibiting FASN can disrupt lipid synthesis, leading to reduced cell proliferation and increased apoptosis, making it a potential therapeutic target.
