How Does GVT Differ from Graft Versus Host Disease (GVHD)?
While both GVT and Graft Versus Host Disease (GVHD) involve the donor’s immune cells attacking the recipient’s cells, they have different targets and outcomes. GVHD is a condition where the donor’s immune cells attack the recipient’s normal tissues, causing complications and potentially severe side effects. In contrast, GVT specifically targets cancer cells, leading to their destruction. The challenge in clinical practice is to maximize the GVT effect while minimizing GVHD.