MDM2 can contribute to cancer development through the overexpression or amplification of the MDM2 gene, leading to the inactivation of p53. Since p53 is a crucial regulator of the cell cycle and apoptosis, its inactivation allows cells to proliferate uncontrollably and evade programmed cell death, fostering a tumorigenic environment. High levels of MDM2 have been observed in various cancers such as sarcomas, breast cancer, and lung cancer.
