How Does Nucleotide Biosynthesis Influence Cancer Progression?
Nucleotide biosynthesis is fundamental for DNA replication and repair, processes that are upregulated in cancer cells. The increased demand for nucleotide synthesis is met through both de novo and salvage pathways. Targeting enzymes involved in these pathways can disrupt DNA synthesis, leading to cell cycle arrest and apoptosis in cancer cells.
Drugs like methotrexate and 5-fluorouracil exploit this vulnerability by inhibiting key steps in nucleotide biosynthesis, serving as effective chemotherapy agents.
