Mutations in the CHEK2 gene are implicated in a variety of cancers. These mutations can lead to the production of a non-functional CHEK2 protein, impairing its ability to respond to DNA damage effectively. This can result in the accumulation of genetic errors, contributing to the development and progression of cancer. CHEK2 mutations have been linked to an increased risk of breast cancer, colorectal cancer, prostate cancer, and other malignancies.
