Are There Any Therapeutic Approaches Targeting CHEK2?
Currently, there are no specific therapies that target CHEK2 directly. However, understanding the role of CHEK2 in DNA repair pathways can inform the use of existing treatments. For example, [PARP inhibitors]( ), which target other DNA repair pathways, may be more effective in cancers with CHEK2 mutations due to the synthetic lethality principle. Ongoing research aims to develop targeted therapies that exploit weaknesses in cancer cells with defective DNA damage response mechanisms.
