What Cancers are Most Commonly Associated with CHEK2 Mutations?
CHEK2 mutations have been linked to several types of cancers, including:
- [Breast Cancer]( ): CHEK2 mutations are associated with an increased risk of both familial and sporadic breast cancer. The 1100delC mutation, in particular, is found more frequently in individuals with breast cancer. - [Colorectal Cancer]( ): Individuals with CHEK2 mutations have a higher risk of developing colorectal cancer. The gene’s role in DNA repair is critical in preventing the accumulation of mutations in rapidly dividing cells of the colon. - [Prostate Cancer]( ): Studies have shown that men with CHEK2 mutations have an elevated risk of prostate cancer. The gene’s involvement in apoptosis and cell cycle regulation is crucial in preventing the uncontrolled growth of prostate cells. - [Lung Cancer]( ): Some studies suggest a possible link between CHEK2 mutations and lung cancer, although this association is less well-established compared to breast and colorectal cancers.
