How is FDR Different from Other Multiple Testing Corrections?
Traditional methods like the Bonferroni correction are overly stringent, often leading to a high rate of false negatives, where true associations are missed. The FDR, on the other hand, is less conservative and more suitable for exploratory studies in cancer research. It adjusts the threshold for significance in a way that controls the proportion of false discoveries, making it a more powerful tool for identifying potential biomarkers and therapeutic targets.
