Genomic profiling typically involves collecting a sample of the tumor tissue, which is then subjected to various sequencing technologies. These technologies include Next-Generation Sequencing (NGS), which allows for high-throughput analysis of multiple genes simultaneously. The data obtained from sequencing is analyzed using bioinformatics tools to identify genetic alterations. Importantly, profiling can also be performed on liquid biopsies, which analyze circulating tumor DNA (ctDNA) in the blood, offering a less invasive option for monitoring cancer.