Genomic profiling can detect a wide array of genetic alterations, including:
- Mutations: Changes in the DNA sequence that may activate oncogenes or inactivate tumor suppressor genes. - Gene Fusions: Abnormal joining of two genes that can result in the production of oncogenic fusion proteins. - Copy Number Variations (CNVs): Changes in the number of copies of a particular gene, which can lead to overexpression or loss of gene function. - Epigenetic Changes: Modifications in gene expression without altering the underlying DNA sequence, such as DNA methylation and histone modification.
