PVT1 is often co-amplified with the oncogene MYC, which is a major driver in many cancers. The co-amplification suggests that PVT1 might play a supportive role in the oncogenic functions of MYC. Studies have shown that PVT1 can act as a competing endogenous RNA (ceRNA), which means it can sequester microRNAs that would otherwise target and degrade MYC mRNA. This interaction helps stabilize the expression of MYC, thereby promoting oncogenesis.
