What is the Mechanism of Action of PVT1 in Cancer?
The mechanisms by which PVT1 exerts its oncogenic effects are multifaceted:
Regulation of MYC: As mentioned, PVT1 can stabilize MYC expression by acting as a ceRNA for MYC-targeting microRNAs. Epigenetic Modulation: PVT1 can recruit chromatin-modifying complexes to specific genomic loci, altering the expression of genes involved in cell growth and survival. Interaction with Proteins: PVT1 has been shown to interact with various proteins, modulating their activity and contributing to oncogenic signaling pathways. Alternative Splicing: PVT1 can influence the alternative splicing of pre-mRNAs, leading to the production of splice variants that may have oncogenic properties.
