Several therapeutic strategies are being explored to counteract MRP1-mediated drug resistance. These include the development of specific MRP1 inhibitors, which aim to block the efflux function of the protein and enhance the effectiveness of chemotherapeutic drugs. Some compounds, like verapamil and probenecid, have shown potential in inhibiting MRP1 activity. Additionally, research is focused on using RNA interference and CRISPR-Cas9 technologies to downregulate or knockout MRP1 expression in cancer cells.
