How Does MRP1 Contribute to Cancer Drug Resistance?
MRP1 contributes to drug resistance by actively effluxing chemotherapeutic agents out of cancer cells, thereby reducing drug accumulation and efficacy. This protein can transport a wide range of anticancer drugs, including anthracyclines, vinca alkaloids, and alkylating agents. By lowering the intracellular concentrations of these drugs, MRP1 enables cancer cells to survive and proliferate despite chemotherapy.
