What is Multidrug Resistance Associated Protein 1 (MRP1)?
Multidrug resistance associated protein 1 (MRP1), also known as ABCC1, is a member of the ATP-binding cassette (ABC) transporter family. It plays a crucial role in transporting various substrates, including drugs and metabolites, across cellular membranes. MRP1 is particularly significant in the context of cancer because it contributes to the multidrug resistance (MDR) phenomenon, which is a major obstacle in cancer therapy.
