read depth normalization

How is Read Depth Normalization Achieved?

Several methods are used to achieve read depth normalization:
1. Down-Sampling: Reducing the number of reads in higher-depth samples to match those with lower depth.
2. RPKM/FPKM/TPM: Normalizing read counts by considering the length of genes and the total number of reads.
3. Quantile Normalization: Aligning the distribution of read counts across samples.
4. DESeq/edgeR: Statistical packages that model read counts and apply normalization techniques.

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