The SMARCA4 gene is frequently mutated or deleted in various types of cancers. Its role in chromatin remodeling means that when it is dysfunctional, the regulation of gene expression can go awry. This can lead to uncontrolled cell growth and tumor development. SMARCA4 mutations have been identified in cancers such as lung adenocarcinoma, small cell carcinoma of the ovary, and non-small cell lung cancer.
