What are the Therapeutic Implications of SMARCA4 Mutations?
The discovery of SMARCA4 mutations in cancer has opened the door to potential targeted therapies. For instance, cancers with SMARCA4 mutations may be more susceptible to treatments that inhibit other components of the SWI/SNF complex. Researchers are also exploring the use of epigenetic drugs that can modify the chromatin state to counteract the effects of SMARCA4 loss.
