The Gleason Score is determined by adding two numbers, each ranging from 1 to 5. These numbers represent the most common (primary pattern) and the second most common (secondary pattern) patterns of cells seen in the prostate tissue. The two numbers are added together to get a score between 2 and 10. A lower score indicates that the cancer cells are more similar to normal cells and are less likely to spread, while a higher score indicates more aggressive cancer.