While the Gleason Score is a valuable tool, it does have limitations: - Subjectivity: The determination of the score relies on the pathologist's interpretation, which can introduce variability. - Sampling Error: The score is based on biopsy samples, which may not represent the entire tumor. This can sometimes result in an underestimation or overestimation of the cancer's aggressiveness. - Evolution: As cancer progresses, the Gleason Score can change, necessitating repeated biopsies for accurate assessment.
