How is Wnt Signaling Pathway Targeted in Cancer Therapy?
Given its central role in several cancers, the Wnt pathway is an attractive target for therapy. Several strategies are being explored to inhibit Wnt signaling in cancer. These include small molecules that inhibit β-catenin/TCF interactions, tankyrase inhibitors that stabilize Axin, and monoclonal antibodies that block Wnt ligands or receptors. Clinical trials are ongoing to evaluate the efficacy and safety of these therapeutic agents.
