Aberrant Wnt signaling is implicated in the pathogenesis of various cancers, including colorectal, breast, lung, and liver cancers. Mutations in components of the Wnt pathway, such as APC, β-catenin, and Axin, can lead to uncontrolled cell proliferation and tumor development. Overactivation of Wnt signaling promotes cancer cell survival, proliferation, and metastasis, making it a critical pathway in oncogenesis.
