What are the Challenges in Targeting the Wnt Pathway?
Despite its potential, targeting the Wnt pathway poses several challenges. The pathway's complexity and involvement in normal tissue homeostasis raise concerns about off-target effects and toxicity. Additionally, redundancy within the Wnt signaling components can make it difficult to achieve effective inhibition. The development of selective and potent inhibitors that can precisely target cancer cells without affecting normal cells remains a significant challenge.
