What are Some Common Applications of FISH in Cancer?
FISH has several important applications in cancer:
HER2 Testing: In breast cancer, FISH is used to detect the amplification of the HER2 gene, which can guide the use of targeted therapies such as trastuzumab. ALK Rearrangement: In non-small cell lung cancer (NSCLC), FISH is used to identify ALK gene rearrangements, which can indicate the potential benefit of ALK inhibitors. Chromosomal Translocations: In leukemias and lymphomas, FISH is used to detect specific chromosomal translocations, such as the BCR-ABL fusion gene in chronic myeloid leukemia (CML).
