Preparing for a cancer walk-a-thon involves several steps. First, participants should register for the event, which may include a registration fee. Next, they should start fundraising by reaching out to their network through social media, emails, or personal appeals. Training for the walk is also important, especially for longer distances. Participants should gradually increase their walking distance, stay hydrated, and wear comfortable clothing and footwear. Additionally, it's advisable to be aware of the weather forecast and bring any necessary items like sunscreen, hats, or rain gear.