5-HT3 receptor antagonists, also known as serotonin receptor antagonists, are a class of medications that block the action of serotonin at the 5-HT3 receptor. These receptors are found in both the central and peripheral nervous system. The primary use of these antagonists in cancer treatment is to manage chemotherapy-induced nausea and vomiting (CINV), a common and debilitating side effect of cancer therapy.
