What are Common In Vivo Models Used in Cancer Research?
Several in vivo models are commonly used in cancer research, each with its advantages and limitations:
Xenograft models: Human cancer cells are implanted into immunocompromised mice. These models are widely used for their ability to mimic human tumor characteristics. Syngeneic models: Mouse cancer cells are implanted into immunocompetent mice of the same genetic background. These models are useful for studying the immune response to cancer treatment. Genetically engineered mouse models (GEMMs): Mice are genetically modified to develop spontaneous tumors. These models closely resemble the genetic and biological features of human cancers.
