What are DNA Methyltransferase Inhibitors (DNMTis)?
DNA Methyltransferase Inhibitors (DNMTis) are a class of drugs designed to inhibit the activity of DNA methyltransferases, enzymes that add methyl groups to DNA. This process, known as DNA methylation, is crucial for regulating gene expression. Aberrant methylation is a common feature in various cancers, leading to the silencing of tumor suppressor genes. By inhibiting DNMTs, DNMTis can potentially reactivate these genes and suppress tumor growth.
