What Are Key Pro Inflammatory Mediators in Cancer?
Among the key mediators are cytokines such as Tumor Necrosis Factor-alpha (TNF-α), Interleukin-6 (IL-6), and Interleukin-1β (IL-1β). These molecules can activate various signaling pathways, including the NF-κB pathway and the JAK/STAT pathway, which are involved in cell survival, proliferation, and differentiation. Chemokines such as CXCL8 (IL-8) also play a role by attracting immune cells to the tumor site, which can sometimes support tumor growth and metastasis.
