Many genes have been identified that, when mutated, can increase the risk of cancer in an autosomal dominant manner. Some notable examples include:
- BRCA1 and BRCA2 genes: Mutations in these genes are strongly associated with an increased risk of breast and ovarian cancers. - APC gene: Mutations in this gene are linked to familial adenomatous polyposis, which significantly increases the risk of colorectal cancer. - TP53 gene: Mutations in TP53 can lead to Li-Fraumeni syndrome, which predisposes individuals to a variety of cancers, including sarcomas and leukemias.
