What Are Some Examples of Successful Molecular Modeling Applications in Cancer?
There have been several notable successes in applying molecular modeling to cancer research:
Imatinib (Gleevec): This drug was developed using structural information about the BCR-ABL protein, a key player in chronic myeloid leukemia. Trastuzumab (Herceptin): Molecular modeling helped in understanding its interaction with the HER2 receptor in breast cancer. EGFR Inhibitors: These were designed based on the structure of the epidermal growth factor receptor, which is involved in several cancers.
