Several critical proteins associated with cancer are well-documented in the PDB. Some of the notable ones include:
1. p53: Often referred to as the "guardian of the genome," p53 is a tumor suppressor protein that plays a vital role in preventing cancer. Mutations in the p53 gene are found in many cancers. 2. HER2: Human Epidermal growth factor Receptor 2 is overexpressed in some breast cancers, and its structure has been pivotal in the development of targeted therapies like trastuzumab (Herceptin). 3. BRCA1 and BRCA2: These proteins are involved in DNA repair and are linked to a higher risk of breast and ovarian cancers. Structural data helps in understanding their function and the impact of mutations. 4. EGFR: Epidermal Growth Factor Receptor is another critical protein in various cancers, especially lung cancer. Structural studies have led to the development of inhibitors like gefitinib and erlotinib.
