What Are the Challenges in Using PDB Data for Cancer Research?
While the PDB is an invaluable resource, there are challenges in using its data for cancer research:
1. Incomplete Data: Not all cancer-related proteins have resolved structures, limiting the comprehensiveness of the data. 2. Static Nature: PDB structures are static snapshots, which may not fully represent the dynamic nature of proteins in vivo. 3. Complexity of Cancer: Cancer is a multifaceted disease with genetic, environmental, and lifestyle factors, making it challenging to attribute structural data to functional outcomes.
