Several [key proteins] form the kinetochore complex, including Ndc80, CENP-A, CENP-B, and CENP-C. Each of these proteins has a unique role in kinetochore assembly and function. For instance, CENP-A is a variant of histone H3 and is essential for the epigenetic marking of centromere location. Ndc80 is crucial for microtubule attachment and tension sensing. Misregulation or mutations in these proteins can disrupt kinetochore function and lead to chromosomal missegregation, contributing to cancer progression.
