In cancer, genomic instability is a hallmark feature, and errors in chromosome segregation can lead to aneuploidy—a condition where cells have an abnormal number of chromosomes. [Kinetochores] are vital for the accurate distribution of chromosomes; therefore, any malfunction or misregulation in kinetochore proteins can contribute to the development of cancer. Aberrant kinetochore function can result in chromosomal instability (CIN), which is frequently observed in various cancers.
