What are some mechanisms by which lncRNAs regulate gene expression?
lncRNAs regulate gene expression through numerous mechanisms:
Chromatin Remodeling: lncRNAs can recruit chromatin-modifying complexes to specific genomic loci, altering the chromatin state and thereby regulating gene expression. Transcriptional Regulation: They can interact with transcription factors or RNA polymerase II to enhance or inhibit the transcription of target genes. Post-Transcriptional Regulation: lncRNAs can bind to messenger RNAs (mRNAs) or microRNAs (miRNAs) to influence mRNA stability and translation.
