Several well-known oncogenes play critical roles in various cancers:
- Ras: Mutations in this gene are found in about 30% of all cancers, including pancreatic, colorectal, and lung cancers. - Myc: This gene is involved in cell cycle progression, apoptosis, and cellular transformation and is implicated in many types of cancer. - HER2: Overexpression of this gene is associated with aggressive breast and ovarian cancers. - BCR-ABL: A product of chromosomal translocation, this fusion gene is a hallmark of chronic myeloid leukemia (CML).
