What are the Advantages of Long Read Sequencing in Cancer Research?
Long read sequencing offers several advantages in the context of cancer research:
Structural Variants: Long reads can more accurately detect structural variants such as insertions, deletions, and inversions, which are often missed by short-read sequencing. Complex Regions: Regions of the genome that are highly repetitive or contain complex rearrangements are more easily sequenced with long reads. Haplotype Phasing: Long read sequencing can phase alleles, enabling a clearer understanding of haplotypes and their contributions to cancer. Gene Fusions: Long reads can identify gene fusions, which are common in various cancers and can serve as potential therapeutic targets.
