What are the Causes of Myeloproliferative Disorders?
The exact cause of MPDs is not fully understood, but most cases are associated with genetic mutations. A significant number of patients with MPDs have mutations in the JAK2 gene, specifically the JAK2 V617F mutation. Other mutations that may be involved include MPL and CALR. These mutations lead to the activation of signaling pathways that promote the proliferation of blood cells.
