What are the Challenges and Future Directions in MGMT Research?
Despite significant advances, several challenges remain in MGMT research: - Toxicity of MGMT inhibitors: Developing inhibitors that are specific and have minimal off-target effects is critical. - Heterogeneity in Tumor Response: Understanding the variability in MGMT expression and promoter methylation across different cancers and within tumors is essential for personalized therapy. - Biomarker Development: More reliable and non-invasive biomarkers for MGMT promoter methylation are needed to guide treatment decisions better.
Future research is likely to focus on these areas to develop more precise and effective cancer therapies. Understanding the underlying mechanisms of MGMT regulation and its interaction with other cellular processes will also be key to overcoming the challenges associated with MGMT-mediated drug resistance.
