What is the Clinical Significance of MGMT Promoter Methylation?
MGMT promoter methylation is an epigenetic modification that silences the expression of the MGMT gene. In the context of cancer, particularly glioblastoma, MGMT promoter methylation status is a crucial biomarker. Patients with methylated MGMT promoters tend to respond better to alkylating agents like temozolomide, as their tumor cells are less efficient at repairing the DNA damage caused by the drug. Therefore, assessing MGMT promoter methylation can guide treatment decisions and predict patient outcomes.
