Given the role of MGMT in drug resistance, several therapeutic strategies are being explored: 1. MGMT Inhibitors: Compounds that inhibit MGMT activity can enhance the efficacy of alkylating agents. However, the development of clinically effective MGMT inhibitors has been challenging due to toxicity and specificity issues. 2. Gene Silencing Approaches: Techniques such as RNA interference (RNAi) and CRISPR-based gene editing are being investigated to reduce MGMT expression in cancer cells, thereby sensitizing them to alkylating chemotherapy. 3. Combination Therapies: Combining MGMT inhibitors or gene silencing techniques with standard chemotherapy may improve treatment outcomes by overcoming drug resistance.
