What are the Challenges and Future Directions in Targeting JAKs in Cancer Therapy?
While JAK inhibitors have shown promise, there are several challenges that need to be addressed. Resistance to JAK inhibitors can develop over time, limiting their long-term efficacy. Additionally, because JAKs are involved in numerous physiological processes, targeting them can lead to adverse side effects such as immunosuppression and increased risk of infections. Future research is focused on developing more selective JAK inhibitors with fewer side effects and understanding the mechanisms of resistance to improve treatment outcomes.
